RICT 2019

Interfacing Chemical Biology and Drug Discovery

55th International Conference on Medicinal Chemistry
55čmes Rencontres Internationales de Chimie Thérapeutique

 Nantes, France    July 3-5, 2019

Programme


07:30

Registration

08:30

RICT 2019 Opening

Prof. Sebastien PAPOT
SCT & UNIVERSITY OF POITIERS, Poitiers, France
Prof. Pascal MARCHAND
UNIVERSITY OF NANTES, Nantes, France
Dr Patricia LEMARCHAND
UNIVERSITY OF NANTES, Nantes, France

Inaugural Conference

Session Chair:

Prof. Sebastien PAPOT
SCT & UNIVERSITY OF POITIERS, Poitiers, France

09:00

PL01: What Makes a Great Medicinal Chemist: Some Fresh Thoughts

Dr Mark MURCKO
RELAY THERAPEUTICS, Cambridge, United States

Session 1: Recent Advances for Cancer Therapy

Session Chair:

Dr Yannick JACQUES
INSERM/CNRS, Nantes, France

09:45

PL02: Reprogramming the Reactivity of Iron in Cancer

Dr Raphaël RODRIGUEZ
INSTITUT CURIE, Paris, France

10:30

Coffee Break and Exhibition

11:00

PL03: Quo Vadis Small Molecule Cancer Therapeutics?

Dr Ingo HARTUNG
BAYER HEALTHCARE, Berlin, Germany

11:45

KL01: Therapeutic Potential of Macrocyclic ALK2 Inhibitors

Dr Pascal BENDERITTER
ONCODESIGN, Dijon, France

12:15

Lunch

13:00

Posters (Odd numbers) and Exhibition

Session 2: Artificial Intelligence in Drug Discovery

Session Chair:

Prof. Pascal BONNET
UNIVERSITY OF ORLÉANS, Orléans, France

14:30

PL04: Massively Multi-target Profile-QSAR: IC50 Predictions Comparable to 4-Concentration Experiments for most Novartis Assays

Dr Eric MARTIN
NOVARTIS, Emeryville, United States

15:15

PL05: Automated Syntheses Planning and its Implications for Drug Design

Mr Marwin SEGLER
BENEVOLENTAI, London, United Kingdom

16:00

Coffee Break and Exhibition

Session 3: Mechanism Based Approaches

Session Chair:

Dr Maria DUCA
UNIVERSITÉ CÔTE D'AZUR, Nice, France

16:30

PL06: Discovery of Risdiplam, a Selective Survival of Motor Neuron-2 (SMN2) Gene Splicing Modifier for the Treatment of Spinal Muscular Atrophy (SMA)

Dr Hasane RATNI
F. HOFFMANN-LA ROCHE LTD, Basel, Switzerland

17:15

PL07: The Influence of Free Ligand Conformations on Mcl-1 PPI Inhibition

Dr Rodrigo CARBAJO
ASTRAZENECA, Cambridge, United Kingdom

18:00

KL02: Tackling a Unique S1 Protease by SBDD - Highly Potent & Selective Factor D Inhibitors - Age-Related Macular Generation (AMD)

Dr Edwige LORTHIOIS
NOVARTIS, Basel, Switzerland

18:30

Welcome and Networking Reception

20:30

End of the day

Session 4: Paul Ehrlich Award Lecture (sponsored by Janssen Research & Development)

Session Chairs:

Dr Luc VAN HIJFTE
SCT & MERCACHEM-SYNCOM, Nijmegen, The Netherlands
Dr Jose CID
JANSSEN R&D, Toledo, Spain

08:45

PL08: Paul Ehrlich Award Lecture - Chemotype - Phenotype - Target

Prof. Herbert WALDMANN
MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY, Dortmund, Germany

Session 5: New Breakthrough in Antibody-based Therapy

Session Chair:

Prof. Marie-Claude VIAUD-MASSUARD
FACULTÉ DES SCIENCES PHARMACEUTIQUES - UNIVERSITÉ DE TOURS, TOURS, France

09:45

PL09: Chemical Physiology of Antibody Conjugates and Natural Products

Dr Goncalo BERNARDES
INSTITUTO DE MEDICINA MOLECULAR, PORTUGAL & UNIVERSITY OF CAMBRIDGE, Lisbon, Portugal

10:30

Coffee Break and Exhibition

11:00

PL10: Click-Cleavable Antibody-Drug Conjugates

Dr Marc ROBILLARD
TAGWORKS PHARMACEUTICALS, Eindhoven, The Netherlands

11:45

PL11: Increasing Brain Exposure of Therapeutic Antibodies

Dr Dominique LESUISSE
SANOFI, Chilly-Mazarin, France

12:30

Lunch

13:00

Posters (Even numbers) and Exhibition

Session 6: Sugars in Drug Discovery

Session Chair:

Prof. Didier DUBREUIL
CEISAM - UNIVERSITY OF NANTES, Nantes, France

14:30

PL12: Carbohydrate-Lectin Interactions - What Makes Them Unique?

Prof. Dr Beat ERNST
UNIVERSITY OF BASEL, Basel, Switzerland

15:15

PL13: Complex Glycans in Health and Disease

Prof. Geert-Jan BOONS
UTRECHT UNIVERSITY, Utrecht, The Netherlands

16:00

Coffee Break and Exhibition

Session 7: New Modalities in Drug Discovery

Session Chair:

Prof. Pascal MARCHAND
UNIVERSITY OF NANTES, Nantes, France

16:30

PL14: Unlocking Drug Discovery Power through Collaborative Efforts between Academia and CRO : Bringing Novel Tankyrase Inhibitors towards the Clinic

Dr Anita WEGERT
MERCACHEM-SYNCOM, Nijmegen, The Netherlands

17:15

PL15: Identification of S 64315, a Potent and Selective Mcl-1 Inhibitor through Fragment-based Drug Discovery

Dr Andras KOTSCHY
SERVIER RESEARCH INSTITUTE OF MEDICINAL CHEMISTRY, Budapest, Hungary

18:00

KL03: Nanofitin Modules Platform: Go Multispecific, Go Multiparatopic !

Dr Anne CHEVREL
AFFILOGIC, Nantes, France

18:30

End of the day

20:30

Banquet

Session 8: New Tools for Therapeutic Innovation

Session Chair:

Prof. Joachim JOSE
UNIVERSITY OF MÜNSTER, Münster, Germany

08:30

PL16: Straightforward Conversion of Peptides into Bioactive Lactam-Based Foldamers

Prof. Muriel AMBLARD
CNRS-UNIVERSTY OF MONTPELLIER I, Montpellier, France

09:15

PL17: Chemical Biology of mRNA Modifications

Prof. Andrea RENTMEISTER
UNIVERSITY OF MÜNSTER, Münster, Germany

10:00

Coffee Break and Exhibition

Session 9: Modifying Proteins Structures and Functions

Session Chair:

Dr Gilles GUICHARD
THE EUROPEAN INSTITUTE OF CHEMISTRY AND BIOLOGY (IECB), Pessac, France

10:30

PL18: Modulating Different Components of the Ubiquitin System with Small Molecules and Cyclic Peptides

Prof. Ashraf BRIK
TECHNION-ISRAEL INSTITUTE OF TECHNOLOGY, Haifa, Israel

11:15

PL19: Cysteine Arylation to Engineer, Deliver, and Discover Proteins

Prof. Bradley Lether PENTELUTE
MASSACHUSETTS INSTITUTE OF TECHNOLOGY, Cambridge, United States

Session 10: Pierre Fabre Award Lecture (Sponsored by Pierre Fabre)

Session Chairs:

Dr Serge GRISONI
CENTRE DE RECHERCHE ET DÉVELOPPEMENT PIERRE FABRE, Toulouse, France
Dr Brigitte LESUR
INSTITUT DE RECHERCHES SERVIER, Croissy-Sur-Seine, France

12:00

PL20: Pierre Fabre Award Lecture - Click Chemistry with Mesoionics: New Tools for Chemical Biology

Dr Frédéric TARAN
CEA/SACLAY, Gif-sur-Yvette, France

13:00

Closing Remarks