RICT 2019

Interfacing Chemical Biology and Drug Discovery

55th International Conference on Medicinal Chemistry

 Nantes, France    July 3-5, 2019

Programme


07:30

Registration

08:30

Introduction

Session 1: Inaugural Conference

09:00

What Makes a Great Medicinal Chemist: Some Fresh Thoughts

Dr Mark MURCKO
RELAY THERAPEUTICS, Cambridge, United States

Session 2: New Strategies for Cancer Therapy

09:45

Reprogramming the Reactivity of Iron in Cancer

Dr Raphaël RODRIGUEZ
INSTITUT CURIE, Paris, France

10:30

Coffee Break and Exhibition

11:00

Empowering Cancer Target Validation with High Quality Chemical Probes

Dr Ingo HARTUNG
BAYER HEALTHCARE, Berlin, Germany

11:45

Therapeutic Potential of Macrocyclic ALK2 Inhibitors

Dr Pascal BENDERITTER
ONCODESIGN, Dijon, France

12:15

Lunch

13:00

Posters and Exhibition

Session 3: Artificial Intelligence in Drug Discovery

14:30

Massively Multi-target Profile-QSAR: IC50 Predictions Comparable to 4-Concentration Experiments for most Novartis Assays

Dr Eric MARTIN
NOVARTIS, Emeryville, United States

15:15

Title to be announced

Dr Marwin SEGLER
BENEVOLENTAI, London, United Kingdom

16:00

Coffee Break and Exhibition

Session 4: Mechanism Based Approaches

16:30

Discovery of Risdiplam, a Selective Survival of Motor Neuron-2 (SMN2) Gene Splicing Modifier for the Treatment of Spinal Muscular Atrophy (SMA)

Dr Hasane RATNI
F. HOFFMANN-LA ROCHE LTD, Basel, Switzerland

17:15

The Influence of Free Ligand Conformations on Mcl-1 PPI Inhibition

Dr Rodrigo CARBAJO
ASTRAZENECA, Cambridge, United Kingdom

18:00

Tackling a Unique S1 Protease by SBDD. Discovery of Highly Potent & Selective Factor D Inhibitors

Dr Edwige LORTHIOIS
NOVARTIS, Basel, Switzerland

18:30

Welcome and Networking Reception

20:30

End of the day

Session 5: Ehrlich Prize Lecture

08:45

Paul Ehrlich Award Lecture - Chemotype, Phenotype, Target

Prof. Herbert WALDMANN
MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY, Dortmund, Germany

Session 6: Advances in Therapeutic Antibodies

09:45

Chemical Physiology of Antibody Conjugates and Natural Products

Dr Goncalo BERNARDES
INSTITUTO DE MEDICINA MOLECULAR, PORTUGAL & UNIVERSITY OF CAMBRIDGE, Cambridge, United Kingdom

10:30

Coffee Break and Exhibition

11:00

Click-Cleavable Antibody-Drug Conjugates

Dr Marc ROBILLARD
TAGWORKS PHARMACEUTICALS, Eindhoven, The Netherlands

11:45

Increasing Brain Exposure of Therapeutic Antibodies

Dr Dominique LESUISSE
SANOFI, Chilly-Mazarin, France

12:30

Lunch

13:00

Posters and Exhibition

Session 7: Sugars in Drug Discovery

14:30

Carbohydrate-Lectin Interactions - What Makes Them Unique?

Prof. Dr Beat ERNST
UNIVERSITY OF BASEL, Basel, Switzerland

15:15

Complex Glycans in Health and Disease

Prof. Geert-Jan BOONS
UTRECHT UNIVERSITY, Utrecht, The Netherlands

16:00

Coffee Break and Exhibition

Session 8: New Breakthroughs in Therapeutic Intervention

16:30

Unlocking Drug Discovery Power through Collaborative Efforts between Academia and CRO : Bringing Novel Tankyrase Inhibitors towards the Clinic

Dr Anita WEGERT
MERCACHEM-SYNCOM, Nijmegen, The Netherlands

17:15

Identification of S 64315, a Potent and Selective Mcl-1 Inhibitor through Fragment-based Drug Discovery

Dr Andras KOTSCHY
SERVIER RESEARCH INSTITUTE OF MEDICINAL CHEMISTRY, Budapest, Hungary

18:00

Protein Engineering for Preclinical Development

Dr Anne CHEVREL
AFFILOGIC, Nantes, France

18:30

End of the day

20:15

Banquet

Session 9: Accessing Novel Chemical Space

08:30

Revisiting Freidinger Lactam for the Development of Bioactive Foldamers

Prof. Muriel AMBLARD
CNRS-UNIVERSTY OF MONTPELLIER I, Montpellier, France

09:15

Chemical Biology of mRNA Modifications

Prof. Andrea RENTMEISTER
UNIVERSITY OF MÜNSTER, Münster, Germany

10:00

Coffee Break and Exhibition

Session 10: Protein Engineering for Therapeutic Innovation

10:30

Modulating Different Components of the Ubiquitin System with Small Molecules and Cyclic Peptides

Prof. Ashraf BRIK
TECHNION-ISRAEL INSTITUTE OF TECHNOLOGY, Haifa, Israel

11:15

Cysteine Arylation to Engineer, Deliver, and Discover Proteins

Prof. Bradley Lether PENTELUTE
MASSACHUSETTS INSTITUTE OF TECHNOLOGY, Cambridge, United States

Session 11: Pierre Fabre Lecture

12:00

Title to be announced

13:00

Closing Remarks