RICT 2018

Interfacing Chemical Biology and Drug Discovery

54th International Conference on Medicinal Chemistry
54èmes Rencontres Internationales de Chimie Thérapeutique

 Strasbourg, France    July 4-6, 2018

Programme


07:30

Registration

09:00

Opening and Inaugural Lecture

Session Chair

Dr Luc VAN HIJFTE
SCT & MERCACHEM-SYNCOM, Nijmegen, The Netherlands

09:30

PL01 - Disrupting Cancer Care & Outcomes by Putting Patients in the Driving Seat

Dr Anne BRUINVELS
PX HEALTHCARE, London, United Kingdom

Session 1 - New Breakthrough in GPCR Structure, Function and Drug Discovery

Session Chair

Dr Luc VAN HIJFTE
SCT & MERCACHEM-SYNCOM, Nijmegen, The Netherlands

10:15

PL02 - Chemogenetic Approachs to Validate Poorly Characterised GPCRS

Prof. Graeme MILLIGAN
UNIVERSITY OF GLASGOW, Glasgow, United Kingdom

11:00

Coffee break and Exhibition

Session Chair

Prof. Dominique BONNET
CNRS-UNIVERSITY OF STRASBOURG, Illkirch, France

11:30

PL03 - Discovery of Balovaptan, a Vasopressin 1a Receptor Antagonist for the Treatment of Autism

Dr Patrick SCHNIDER
ROCHE PHARMACEUTICAL, Basel, Switzerland

12:15

PL04 - Ghrelin Receptor Ligands: from the Bench to the Drug on the Market

Dr Jean-Alain FEHRENTZ
CNRS-UNIVERSITY OF MONTPELLIER, Montpellier, France

13:00

Lunch

13:30

Poster session and Exhibition

Session sponsored by Sanofi

Session Chair

Dr Gilbert MARCINIAK
SANOFI, Strasbourg, France

15:00

PL05 - Structure-Based Drug Discovery for G Protein-Coupled Purine Receptors

Prof. Kenneth A. JACOBSON
NIDDK, Bethesda, United States

15:45

PL06 - Structure-guided Development of Selective GPCR Ligands

Prof. Peter GMEINER
FRIEDRICH ALEXANDER UNIVERSITY, Erlangen, Germany

16:30

Coffee break and Exhibition

Session 2 - Novel Synthetic Methods For Therapeutic Innovation (sponsored by the LabEx MEDALIS)

Session Chair

Dr Alain WAGNER
CNRS/UNIVERSITY OF STRASBOURG, Illkirch, France

17:00

PL07 - Late Stage Fluorination for Medicine

Prof. Véronique GOUVERNEUR
UNIVERSITY OF OXFORD, Oxford, United Kingdom

17:45

PL08 - Single Electron Processes Enabling Organic Synthesis

Prof. Gary A. MOLANDER
UNIVERSITY OF PENNSYLVANIA, Philadelphia, United States

18:30

Welcome and networking reception

Session sponsored by Janssen Research & Development

Session Chair

Prof. Sebastien PAPOT
SCT & UNIVERSITY OF POITIERS, Poitiers, France
Ms Sandrine GROSSE
JANSSEN, Beerse, Belgium

08:30

PL09 - Paul Ehrlich Award Lecture - Chemical Biology on the Genome

Prof. Sir Shankar BALASUBRAMANIAN
UNIVERSITY OF CAMBRIDGE, Cambridge, United Kingdom

09:30

Start of sessions

Session 3 - Biologically Active Chemical Space
Session 4 - Chemokine Targeted Drug Discovery
Session 3 - Biologically Active Chemical Space
Session Chair
Prof. Sebastien PAPOT
SCT & UNIVERSITY OF POITIERS, Poitiers, France
09:30
PL10 - Ancient and Modern Scaffolds for Biologically Active Chemical Space
Prof. Arasu GANESAN
UNIVERSITY OF EAST ANGLIA, Norwich, United Kingdom
Session 4 - Chemokine Targeted Drug Discovery
Session Chair
Dr Sébastien ALBRECHT
UNIVERSITY OF HAUTE-ALSACE, Mulhouse, France
PL11 - Identification of Chemokine Neutraligands Targeting Atopic Diseases and Hyperalgesia
Dr Jean-Luc GALZI
CNRS-UNIVERSITY OF STRASBOURG, Illkirch, France
10:15

Coffee break and Exhibition

11:00

Start of sessions

Session 5 - Advances in GPCR drug discovery
Session 6 - Advances in Biological Imaging
Session 5 - Advances in GPCR drug discovery
Session Chair
Prof. Marcel HIBERT
UNIVERSITÉ DE STRASBOURG, ILLKIRCH, France
11:00
KL01 - Discovery of The Clinical Candidate Ribuvaptan, a Dual Acting Vasopressin V1a/V2 Receptor Antagonist for the Treatment of Heart Failure
Dr Carsten SCHMECK
BAYER, Wuppertal, Germany
11:30
KL02 - Discovery of New Brain Penetrating Neuropeptide S Receptor (NPSR) Antagonists
Dr Julien POTHIER
IDORSIA PHARMACEUTICALS LTD., Allschwil, Switzerland
Session 6 - Advances in Biological Imaging
Session Chair
Dr Maria DUCA
UNIVERSITÉ CÔTE D'AZUR, Nice, France
KL03 - Dye-loaded Lipid Nanoparticles: Contrast Agents for Image-guided Surgery and Tools for Drug Delivery
Dr Isabelle TEXIER
LETI-HEALTH, Grenoble, France
KL04 - Inducible Chemical-genetic Fluorescent Markers for Bioimaging
Dr Arnaud GAUTIER
ECOLE NORMALE SUPÉRIEURE, Paris, France
12:00

Lunch

12:30

Poster session and Exhibition

13:00

Career Session

14:00

Start of sessions

Session 7 - Challenging Targets and Approaches (sponsored by Institut de Recherche Servier)
Session 8 - Understanding Binding Characteristics
Session 7 - Challenging Targets and Approaches (sponsored by Institut de Recherche Servier)
Session Chair
Dr Arnaud LE TIRAN
INSTITUT DE RECHERCHES SERVIER, Croissy sur Seine, France
14:00
PL12 - Discovery of Foliglurax, an mGluR4 PAM for the Treatment of Parkinson’s Disease
Dr Stephan SCHANN
DOMAIN THERAPEUTICS SA, Illkirch, France
14:45
PL13 - Potential Therapeutic Targets in the Brain Renin-Agiotensin and Apelinergic Systems for Treatment of Cardiovascular Diseases
Dr Catherine LLORENS-CORTES
INSERM/COLLÈGE DE FRANCE, Paris, France
15:30
KL05 - Topical Intestinal Agonists of the Bile Acid Receptor TGR5: Controlling Target Engagement by Innovative Molecular Engineering
Dr Julie CHARTON
UNIVERSITY OF LILLE, INSTITUT PASTEUR DE LILLE, Lille, France
Session 8 - Understanding Binding Characteristics
Session Chair
Prof. Didier ROGNAN
CNRS/UNIVERSITY OF STRASBOURG, Illkirch, France
PL14 - Pharmacophore-based Analysis of Molecular Dynamics Trajectories: Towards Understanding KD of Protein Ligands
Prof. Thierry LANGER
UNIVERSITY OF VIENNA, Vienna, Austria
PL15 - Identifying Inter-Helical Interactions Involved in GPCR Structure-Function and the Forces that Determine Receptor-Ligand Residence Time
Dr Alexander HEIFETZ
EVOTEC, Abingdon, United Kingdom
KL06 - Drug-target Residence Time – a Misleading Concept
Dr Rutger FOLMER
MERCACHEM, Nijmegen, The Netherlands
16:00

Coffee break and Exhibition

16:30

Start of sessions

Session 9 - Tackling Challenges in Drug Delivery
Session 10 - Chemistry Driven Biological Exploration
Session 9 - Tackling Challenges in Drug Delivery
Session Chair
Prof. Line BOUREL
FACULTÉ DE PHARMACIE, ILLKIRCH, France
16:30
PL16 - Cellular Delivery and Oral Uptake of Cyclic Peptides
Dr Thomas VORHERR
NOVARTIS, Basel, Switzerland
17:15
PL17 - Nanoparticle-based Strategies in Oncology
Prof. Jean-Pierre BENOIT
UNIVERSITY OF ANGERS, Angers, France
Session 10 - Chemistry Driven Biological Exploration
Session Chair
Prof. Stefan LAUFER
UNIVERSITY OF TÜBINGEN, Tübingen, Germany
PL18 - Chemistry as the Helping Tool to Develop New Therapeutic Strategies
Prof. Maria Luz LOPEZ RODRIGUEZ
COMPLUTENSE UNIVERSITY OF MADRID, Madrid, Spain
PL19 - Chemical Tools to Probe Reversible Lysine Acetylation
Prof. Manfred JUNG
ALBERT LUDWIGS UNIVERSITY OF FREIBURG, Freiburg, Germany
20:00

Banquet

Session 11 - New modalities in Drug Discovery (sponsored by Institut de Recherche Pierre Fabre)

Session Chair

Dr Pascal GEORGE
SCT & INDEPENDENT SCIENTIFIC EXPERT & ADVISER, Longvilliers, France
Mr Philippe SCHAMBEL
INSTITUT DE RECHERCHE PIERRE FABRE, TOULOUSE, France

08:30

PL20 - The Confobody Technology, a New Platform to Enable Fragment Screening on GPCRs

Dr Christel MENET
CONFO THERAPEUTICS, Brussels, Belgium

09:15

PL21 - Pierre Fabre Award lecture
PROTAC-mediated Protein Degradation: A New Therapeutic Modality

Prof. Craig CREWS
UNIVERSITY OF YALE, New Haven, United States

10:00

Coffee break and Exhibition

Session 12 - Chemistry in Living Systems

Session Chair

Prof. Rebecca DEPREZ-POULAIN
UNIVERSITY OF LILLE, Lille, France

10:30

PL22 - Two Adventures in Chemical Biology - in vivo Chemistry and Real-time Optical Medical Imaging

Prof. Mark BRADLEY
UNIVERSITY OF EDINBURGH, Edinburgh, United Kingdom

11:15

PL23 - Therapeutic In Vivo Synthetic Chemistry

Prof. Nori TANAKA
RIKEN, Saitama, Japan

12:00

Concluding remarks

Prof. Pascal MARCHAND
UNIVERSITY OF NANTES, Nantes, France
Prof. Sebastien PAPOT
SCT & UNIVERSITY OF POITIERS, Poitiers, France